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High-Dose NMN Supplement for Safety and Assurance.

1. Marui Pharmaceuticals NMN25000 Product Overview

  • Content: 90 capsules
  • Price     :178,500JPY
  • NMN Raw Material Purity Analysis  :99.5%
  • NMN content per capsule :166.6mg

2. NMN Intravenous Therapy (Anti-Aging)

■ NMN is a dream substance for the next generation of anti-aging

NMN is a substance similar to vitamins that is naturally produced in the body. However, its production decreases with age. The reduction of NMN in the body is believed to initiate the aging process and lead to the deterioration of physical and cognitive functions.

Research studies have discovered that consuming NMN can cause dramatic changes in the appearance and function of the body, akin to turning back the hands of a clock. As a result, NMN has garnered global attention as an "anti-aging drug."

As for foods that contain high levels of NMN, examples include edamame, broccoli, and cucumbers. However, consuming approximately 100mg of NMN from broccoli alone would require an enormous amount of around 40kg (approximately 2000 bunches). By receiving NMN through intravenous drip, it can be efficiently absorbed by the body.

Professor David Sinclair of Harvard Medical School stated the following about NMN: In mice that were 22 months old, which is equivalent to 60 years of age in humans, NMN was administered. After just one week, their muscles had transformed to resemble those of mice that were 6 months old, which is equivalent to 20 years old in humans. In other words, within a short period of one week, they achieved a rejuvenation equivalent to 40 years in humans.

No negative aspects of NMN have been discovered thus far. On the contrary, it has been found to have protective effects on eye diseases, hearing loss, liver, and heart. Additionally, when administered to mice with liver cancer, the tumors disappeared. It appears to be a panacea, and these are facts confirmed by research laboratories worldwide.

David・A・Sinclair

Professor of Genetics at Harvard Medical School. Selected as one of Time magazine's "100 Most Influential People" and one of the "Top 50 People in Healthcare." Appeared on NHK Special program "Next World: Our Future." Has published over 170 scientific papers and contributed to the development of over 50 patents.

NMN Research Report

  1. When NMN was administered to female mice, their lifespan was extended by 16%.
  2. When NMN was administered to diabetic mice for one week, their blood sugar levels normalized.
  3. When NMN was administered to mice at the age of 22 months (equivalent to 60 years in humans), their cells reverted to a state resembling those of mice at the age of 6 months (equivalent to 20 years in humans).

3.NMN Intravenous Therapy Activates the Sirtuin Gene

■ Various benefits of sirtuin gene activation

When the Sirtuin gene is activated, DNA repair is enhanced, memory improves, endurance increases, and it becomes easier to maintain a healthy weight. The protein Sirtuin, synthesized through the activation of the Sirtuin gene, has evolved to regulate human health, physical fitness, and overall survival. The activity of Sirtuin requires the presence of NAD+ molecules as essential fuel. However, with aging, NAD+ levels decline, leading to a decline in Sirtuin function, which is believed to contribute to the development of age-related diseases.

Furthermore, the Sirtuin gene, known as the "guardian of the genome," plays an essential role in maintaining cellular health. The protein Sirtuin, synthesized through the activation of the Sirtuin gene, serves as a class of enzymes responsible for cellular stress response and damage repair. Sirtuin also plays a role in insulin production, neurodegenerative diseases, diabetes, and other age-related health conditions and processes. The activation of Sirtuin requires the presence of NAD+.

4.About the Anti-Aging Component NAD+ 

■ NMN as a supplemental source of NAD+ production

The rejuvenating compound NMN is absorbed into the body and converted into a substance called NAD+ which is then delivered to every corner of the body. NAD+ is an essential coenzyme necessary for life and cellular function. Enzymes are substances that facilitate physiological and biochemical processes, and coenzymes are the auxiliary molecules required for enzyme function. NAD+ is one of the most abundant molecules in the body, second only to water, and without it, organisms would perish. NAD+ is utilized by many proteins throughout the body, such as Sirtuin, which repairs damaged DNA. Animal experiments have shown promising results in the field of age-related diseases, such as metabolism, diabetes, heart disease, neurodegenerative disorders, and declining immune function, indicating the ability of increased levels of NAD+ in the body to slow down aging.

NAD+ exists in the bodies of all living organisms and influences youthfulness and health maintenance, but it gradually declines after reaching its peak in the late teenage years. Furthermore, by the age of 40, it can decrease to half of its peak level, resulting in the loss of youthful vitality.

Therefore, supplementing with NMN, the precursor of NAD+, is an effective way to increase the concentration of NAD+ in the body.

■ Why is NAD+ important?

NAD+ is an essential coenzyme necessary for life and cellular function. Enzymes are substances that facilitate physiological and biochemical processes. Coenzymes, on the other hand, are auxiliary molecules required for the function of enzymes. NAD+ is one of the most abundant molecules in the body, second only to water, and without it, organisms would perish. NAD+ is utilized by many proteins throughout the body, such as Sirtuin, which repairs damaged DNA. Animal experiments have shown promising results in the field of age-related diseases, such as metabolism, diabetes, heart disease, neurodegenerative disorders, and declining immune function, indicating the ability of increased levels of NAD+ in the body to slow down aging.

5. Effects of NMN Supplements

■ Consumer feedback on NMN supplements

The results of a survey conducted at clinics in Japan on patients who actually took NMN supplements are as follows.

  •     I have noticed a reduction in blemishes and wrinkles, experiencing rejuvenation of my skin. 
  •     My skin has become smoother and more refined. 
  •     I can sleep soundly and wake up feeling refreshed in the morning. 
  •     My body movements have improved, and I have gained confidence in my physical fitness. 
  •     My concentration has increased, leading to improved efficiency at work. 
  •     The blurriness in my vision has disappeared, and I can see clearly now. 
  •     I'm delighted to see a slight decrease in my weight. 
  •     The roughness in my hands has disappeared. 
  •     My skin has become glossy and radiant.

■ Diseases that can be expected to improve

  • •  Aging (Anti-Aging Care): Improves the increase of aging genes.
  • •  Neurological Disorders: Helps restore functional impairments associated with neurological disorders.
  • •  Diabetes: Restores decreased NAD+ levels and improves abnormal blood sugar levels.
  • •  Eye Function: Confirmed effectiveness in addressing age-related changes in the eyes.
  • •  Alzheimer's Disease: Effectively reduces β-amyloid production, amyloid plaque burden, synaptic loss, and more.
  • •  Cerebral Hemorrhage: Influences the resolution of vascular insufficiency due to aging and has antioxidant effects.
  • •  Obesity and its complications: Improves muscle and liver function through the activation of mitochondria.
  • •  Ischemia-Reperfusion Injury: Activates Sirtuin 1 (enzyme) to protect the heart from damage during ischemia-reperfusion.